Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer.
Braun, M S Adab, Fawzi Bradley, C McAdam, K Thomas, G Wadd, N J Rea, D Philips, R Twelves, C Bozzino, J
Braun, M S
Adab, Fawzi
Bradley, C
McAdam, K
Thomas, G
Wadd, N J
Rea, D
Philips, R
Twelves, C
Bozzino, J
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Abstract
We previously reported high activity for oxaliplatin and a modified de Gramont regimen (OxMdG) in a single centre study of patients with metastatic colorectal cancer. We now report results with a further 56 patients treated at 14 centres. Low rates of grade 3 and 4 toxicity were seen, with no toxic deaths. Objective response rates were CR/PR=53%; NC=34.7%; PD=12.2%. Median time to progression was 8.3 months and overall survival was 14.5 months. This regimen is more convenient than those based around the conventional de Gramont regimen but is highly active and well tolerated; it forms part of a current UK MRC phase 3 trial.
Description
Date
2003-10-06
Publisher
Collections
Keywords
Colorectal Cancer
Type
Article
Citation
Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer. 2003, 89 (7):1155-8 Br. J. Cancer