Publication

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

Labib, Karim
Citations
Altmetric:
Abstract
Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of recent studies has shed new light on the targets of Cdc7 and CDK, indicating that chromosome replication probably initiates by a fundamentally similar mechanism in all eukaryotes.
Authors
Labib, Karim
Affiliation
Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom. klabib@picr.man.ac.uk
Description
Date
2010-06-15
Publisher
Collections
All Paterson Institute for Cancer Research
Show all metadata
Keywords
Type
Article
Citation
How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? 2010, 24 (12):1208-19 Genes Dev
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/109425
Embedded videos