The interaction with tubulin of a series of stilbenes based on combretastatin A-4.
Woods, J A Hadfield, John A Pettit, G R Fox, Brian W McGown, Alan T
Woods, J A
Hadfield, John A
Pettit, G R
Fox, Brian W
McGown, Alan T
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Abstract
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.
Description
Date
1995-04
Publisher
Collections
Keywords
Leukaemia P388
Cultured Tumour Cells
Cultured Tumour Cells
Type
Article
Citation
The interaction with tubulin of a series of stilbenes based on combretastatin A-4. 1995, 71 (4):705-11 Br. J. Cancer