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Classification of formalin-fixed bladder cancer cells with laser tweezer Raman spectroscopy
Tang, N. T. Robinson, Richard Snook, R. D. Brown, Michael D Clarke, Noel W Gardner, P.
Tang, N. T.
Robinson, Richard
Snook, R. D.
Brown, Michael D
Clarke, Noel W
Gardner, P.
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Abstract
Bladder cancer is a common cancer that is relatively hard to detect at an early stage because of its non-obvious symptoms. It is known that bladder cells can be found in urine samples which potentially could be used for early detection of bladder cancer. Raman spectroscopy is a powerful non-invasive tool for accessing biochemical information of cells. Combined with laser tweezers, to allow isolation of single cells, Raman spectroscopy has been used to characterise a number of bladder cells that might be found in a urine sample. Using principal component-canonical variates analysis (PC-CVA) and k-fold validation, the results shows that the invasive bladder cancer cells can be identified with accuracy greater than 87%. This demonstrates the potential of developing an early detection method that identifies the invasive bladder cancer cells in urine samples.
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Date
2023
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Article
Citation
Tang NT, Robinson R, Snook RD, Brown M, Clarke N, Gardner P. Classification of formalin-fixed bladder cancer cells with laser tweezer Raman spectroscopy. The Analyst. 2023 Jul 24. PubMed PMID: 37486734. Epub 2023/07/24. eng.