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Tumourigenic non-small cell lung cancer mesenchymal circulating tumour cells - a clinical case study.

Morrow, Christopher J
; 
Trapani, Francesca
; 
Metcalf, Robert
; 
Bertolini, G
; 
Hodgkinson, Cassandra L
; 
Khandelwal, Garima
; 
Kelly, Paul
; 
Galvin, Melanie
; 
Carter, Louise
; 
Simpson, Kathryn L
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Abstract
Over the past decade numerous reports describe the generation and increasing utility of non-small cell lung cancer (NSCLC) patient-derived xenografts (PDX) from tissue biopsies. While PDX have proven useful for genetic profiling and preclinical drug testing, the requirement of a tissue biopsy limits the available patient population, particularly those with advanced oligometastatic disease. Conversely, 'liquid biopsies' such as circulating tumour cells (CTCs) are minimally invasive and easier to obtain. Here we present a clinical case study of NSCLC patient with advanced metastatic disease, a never smoker whose primary tumour was EGFR and ALK wild type. We demonstrate for the first time, tumorigenicity of their CTCs to generate a patient CTC Derived eXplant (CDX).
Authors
Morrow, Christopher J
Trapani, Francesca
Metcalf, Robert
Bertolini, G
Hodgkinson, Cassandra L
Khandelwal, Garima
Kelly, Paul
Galvin, Melanie
Carter, Louise
Simpson, Kathryn L
Williamson, Stuart
Wirth, Christopher
Simms, Nicole
Franklin, Lynsey
Frese, Kristopher K
Rothwell, Dominic G
Nonaka, Daisuke
Miller, Crispin J
Brady, Ged
Blackhall, Fiona H
Dive, Caroline
Affiliation
Clinical and Experimental Pharmacology Group, University of Manchester, Manchester
Description
Date
2016-03-24
Publisher
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All Christie Publications
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Type
Article
Citation
Tumourigenic Non-Small Cell Lung Cancer Mesenchymal Circulating Tumour Cells - A Clinical Case Study. 2016: Ann Oncol
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/605256
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