Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?
Cooper, R Sarioğlu, S Sökmen, S Füzün, M Küpelioğlu, A Valentine, Helen R Görken, I B Airley, R West, Catharine M L
Cooper, R
Sarioğlu, S
Sökmen, S
Füzün, M
Küpelioğlu, A
Valentine, Helen R
Görken, I B
Airley, R
West, Catharine M L
Citations
Altmetric:
Abstract
The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1-12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10-50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0-2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.
Description
Date
2003-09-01
Publisher
Collections
Keywords
Rectal Cancer
Biological Tumour Markers
Biological Tumour Markers
Type
Article
Citation
Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? 2003, 89 (5):870-6 Br. J. Cancer