Prognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood.
Dias, P Kumar, Patricia Marsden, Henry B Gattamaneni, Rao Kumar, Shant
Dias, P
Kumar, Patricia
Marsden, Henry B
Gattamaneni, Rao
Kumar, Shant
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Abstract
A study of DNA content by flow cytometry revealed a significant difference between rhabdomyosarcomas, which were mainly non-diploid, and other sarcomas of children which were mainly diploid (p = 0.01). There was no association between DNA ploidy and survival or aggressive behaviour of the tumour as indicated for example by advanced clinical stage or unfavourable histology. While DNA ploidy correlated with age, it did not correlate with any other clinical characteristic. The apparent lack of prognostic value of DNA content may have been masked by some high CV values and overridden by the effect of chemotherapy which was the most significant variable in determining a patient's survival (p = 0.00005).
Affiliation
Description
Date
1992
Publisher
Collections
Keywords
Cancer DNA
Cancer Staging
Cancer Staging
Type
Article
Citation
Prognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood., 12 (4):1173-7 Anticancer Res