The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.
Just, Ursula Kan, On Fennelly, Jan Dexter, T Michael Spooncer, Elaine
Just, Ursula
Kan, On
Fennelly, Jan
Dexter, T Michael
Spooncer, Elaine
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Abstract
The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells.
Description
Date
1995
Publisher
Collections
Keywords
Cancer Proteins
Haematopoietic Stem Cells
Murine Virus Leukaemia
Haematopoietic Stem Cells
Murine Virus Leukaemia
Type
Article
Citation
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. 1995, 12 (3):173-7 Growth Factors