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Human breast epithelial stem cells and their regulation.

Kalirai, Helen
; 
Clarke, Robert B
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Abstract
This review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours.
Authors
Kalirai, Helen
Clarke, Robert B
Affiliation
Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK.
Description
Date
2006-01
Publisher
Collections
All Paterson Institute for Cancer Research
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Keywords
Breast Cancer
Cancer Genes
Type
Article
Citation
Human breast epithelial stem cells and their regulation. 2006, 208 (1):7-16 J. Pathol.
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/72713
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