Method validation of circulating tumour cell enumeration at low cell counts.
Cummings, Jeffrey Morris, Karen Zhou, Cong Sloane, Robert Lancashire, Matthew Morris, Daniel Bramley, Stephen Krebs, Matthew G Khoja, Leila
Cummings, Jeffrey
Morris, Karen
Zhou, Cong
Sloane, Robert
Lancashire, Matthew
Morris, Daniel
Bramley, Stephen
Krebs, Matthew G
Khoja, Leila
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Abstract
Circulating tumour cells (CTC) are receiving increasing attention as prognostic, predictive and pharmacodynamic biomarkers in cancer patients. However, their clinical significance can be dependent on an accurate determination of CTC around cut-off values at low cell counts (<10 cells/7.5 ml). Consequently, we have conducted method validation of the CellSearch™ system focusing on clinical samples containing CTC in the cut-off region.
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Date
2013
Publisher
Collections
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Type
Article
Citation
Method validation of circulating tumour cell enumeration at low cell counts. 2013, 13:415 BMC Cancer