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Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation
Raiber, Eun-Ang Wilkinson, James A Manetti, Fabrizio Botta, Maurizio Deakin, Jon A Gallagher, John T Lyon, Malcolm Ducki, Sylvie W
Raiber, Eun-Ang
Wilkinson, James A
Manetti, Fabrizio
Botta, Maurizio
Deakin, Jon A
Gallagher, John T
Lyon, Malcolm
Ducki, Sylvie W
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Abstract
The synthesis of simple, non-sugar glycosaminoglycan (GAG) mimics has been achieved and the analogues evaluated for their ability to inhibit the activation of the MET receptor by hepatocyte growth factor/scatter factor (HGF/SF).
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Date
2007-11-15
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Article
Citation
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation. 2007, 17 (22):6321-5 Bioorg. Med. Chem. Lett.