R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study.
Pappo, A Patel, S Crowley, J Reinke, D Kuenkele, K Chawla, S Toner, G Maki, R Meyers, P Chugh, R
Pappo, A
Patel, S
Crowley, J
Reinke, D
Kuenkele, K
Chawla, S
Toner, G
Maki, R
Meyers, P
Chugh, R
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Abstract
The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma family of tumors (ESFT). We conducted a multicenter phase II study of the fully human IGF-1R monoclonal antibody R1507 in patients with recurrent or refractory ESFT.
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Date
2011-12-01
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R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research through Collaboration study. 2011, 29 (34):4541-7 J Clin Oncol