Protection and selection for gene therapy in the hematopoietic system.
Milsom, Michael D Fairbairn, Leslie J
Milsom, Michael D
Fairbairn, Leslie J
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Abstract
Hematopoietic stem cell gene therapy is potentially curative for a number of inherited and acquired disorders. However, poor gene transfer and expression in repopulating hematopoietic stem cells attenuate this potential. Here we review potential means of conferring a selective advantage to hematopoietic stem cells and their progeny, and discuss the issues that surround the use of selective advantages in vivo.
Authors
Description
Date
2004-02
Publisher
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Keywords
Haematopoietic System
Type
Article
Citation
Protection and selection for gene therapy in the hematopoietic system. 2004, 6 (2):133-46 J Gene Med