A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV).
Matsushita, M Nonaka, Daisuke Iwasaki, T Kuwamoto, S Murakami, I Kato, M Nagata, K Kitamura, Y Hayashi, K
Matsushita, M
Nonaka, Daisuke
Iwasaki, T
Kuwamoto, S
Murakami, I
Kato, M
Nagata, K
Kitamura, Y
Hayashi, K
Citations
Altmetric:
Abstract
Approximately 80% of Merkel cell carcinomas (MCCs) harbor Merkel cell polyomavirus (MCPyV) which monoclonally integrates into the genome and has prognostic significance. The presence or absence of MCPyV is usually diagnosed using CM2B4 immunohistochemistry (IHC) for MCPyV-large T antigen (LT) protein. However, this method poses a risk of misdiagnosis.
Description
Date
2014
Publisher
Collections
Keywords
Type
Article
Citation
A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV). 2014, 9:65 Diagn Pathol