Cell adhesion in the stromal regulation of haemopoiesis.
Clark, B R Gallagher, John T Dexter, T Michael
Clark, B R
Gallagher, John T
Dexter, T Michael
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Abstract
Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.
Affiliation
Description
Date
1992-07
Publisher
Collections
Keywords
Haematologic Diseases
Haematopoiesis
Haematopoietic Cell Growth Factors
haematopoietic Stem Cells
Haematopoietic System
Haematopoiesis
Haematopoietic Cell Growth Factors
haematopoietic Stem Cells
Haematopoietic System
Type
Article
Citation
Cell adhesion in the stromal regulation of haemopoiesis. 1992, 5 (3):619-52 Baillieres Clin. Haematol.