Fluorescent location of malignant cells in fine needle aspirates.
Steven, F S El-Teraifi, H Denton, J Markidou, S G Delinassios, J G
Steven, F S
El-Teraifi, H
Denton, J
Markidou, S G
Delinassios, J G
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Abstract
Malignant cells in fine needle aspirates possess a cell surface protease which can be targeted with fluorescent affinity probes. Cells with active GB exhibit cell surface fluorescence when stained with such affinity probes. The nuclei of all cells on the slides can be counterstained with a nuclear fluorescent stain. Malignant cells are then located by their cell surface fluorescence and their diagnosis confirmed by examining their fluorescent nuclei. Normal cells and benign cells exhibit no cell surface fluorescence and can be ignored. This technique can be used to rapidly select cells of cytological interest in FNA samples obtained routinely and might be adapted for automated screening of FNA.
Description
Date
2000
Publisher
Collections
Keywords
Cancer
Cancer Pathology
Cancer Pathology
Type
Article
Citation
Fluorescent location of malignant cells in fine needle aspirates., 20 (6C):4871-6 Anticancer Res.