Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01).
Le Péchoux, C Laplanche, A Ciuleanu, T Wanders, R Lerouge, D Keus, R Hatton, M Videtic, G M Senan, S
Le Péchoux, C
Laplanche, A
Ciuleanu, T
Wanders, R
Lerouge, D
Keus, R
Hatton, M
Videtic, G M
Senan, S
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Abstract
We recently published the results of the PCI99 randomised trial comparing the effect of a prophylactic cranial irradiation (PCI) at 25 or 36 Gy on the incidence of brain metastases (BM) in 720 patients with limited small-cell lung cancer (SCLC). As concerns about neurotoxicity were a major issue surrounding PCI, we report here midterm and long-term repeated evaluation of neurocognitive functions and quality of life (QoL).
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Date
2011-05
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Article
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Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). 2011, 22 (5):1154-63 Ann. Oncol.