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Chemotherapy of metastatic carcinoma of the breast.
Hancock, B Todd, Ian D Wilkinson, Peter M
Hancock, B
Todd, Ian D
Wilkinson, Peter M
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Abstract
Thirty-four patients with metastatic breast carcinoma were treated with the following combination: methotrexate 60 mg/m2 i.v. days 1 and 8,5-fluorouracil 500 mg/m2 i.v. days 1 and 8, cyclophosphamide 100 mg/m2 daily for 14 days, and prednisolone 25 mg b.d. by mouth daily for 14 days. In 21/34 (62%) patients regression of tumour was maintained for at least three months and in six (18%) this was complete. The median duration of response was 15 months (range 6--33) and there was a significant difference in survival between responders and non-responders (P<0.01). Toxicity was acceptable although dose reduction was necessary in eight patients and in three patients treatment had to be discontinued.
Authors
Description
Date
1980-07
Publisher
Collections
Keywords
Breast Cancer
Type
Article
Citation
Chemotherapy of metastatic carcinoma of the breast. 1980, 31 (4):433-6 Clin Radiol