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LSD1 inhibitors disrupt the GFI1 transcription repressor complex.
Maiques-Diaz, Alba Lynch, James T Spencer, Gary J Somervaille, Tim C P
Maiques-Diaz, Alba
Lynch, James T
Spencer, Gary J
Somervaille, Tim C P
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Abstract
Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
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2018
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LSD1 inhibitors disrupt the GFI1 transcription repressor complex. 2018, 5(4): e1481813 Mol Cell Oncol