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Mitochondrial dynamics and apoptosis: a painful separation.

James, Dominic I
; 
Martinou, Jean-Claude
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Abstract
Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.
Authors
James, Dominic I
Martinou, Jean-Claude
Affiliation
Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
Description
Date
2008-09
Publisher
Collections
All Paterson Institute for Cancer Research
Clinical and Experimental Pharmacology Group
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Keywords
Apoptosis
Mitochondrial Structure
Type
Article
Citation
Mitochondrial dynamics and apoptosis: a painful separation. 2008, 15 (3):341-3 Dev. Cell
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/56015
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