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Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.
Magee, Brian Swindell, Ric Harris, Martin Banerjee, Saumitra S
Magee, Brian
Swindell, Ric
Harris, Martin
Banerjee, Saumitra S
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Abstract
Prognostic factors predicting for breast recurrence following breast conserving surgery and radiotherapy have been identified in a prospective randomised trial comparing two different radiotherapy techniques. The first used megavoltage radiation to encompass the whole breast and regional nodes (WF group). The second used an electron field directed to the tumour bed only (LF group). With a median follow up of 8 years survival in both groups was the same (72%). There was an increased rate of breast recurrence in the LF group: 25%, compared to the WF group: 13% (P = 0.00008), expressed in actuarial terms at 8 years. In a multivariate analysis of factors predicting for breast recurrence, once the difference in treatment technique is allowed for, only two factors were found to be significant: histological grade (P = 0.013) and lymphovascular invasion in the histological specimen (P = 0.037).
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Description
Date
1996-06
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Collections
Keywords
Breast Cancer
Cancer Recurrence
Cancer Recurrence
Type
Article
Citation
Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. 1996, 39 (3):223-7 Radiother Oncol