Loading...
The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
Valpione, Sara Mundra, Piyushkumar A Galvani, Elena Campana, Luca G De Rosa, F. Gupta, Avinash Weightman, John Mills, Sarah Dhomen, Nathalie
Valpione, Sara
Mundra, Piyushkumar A
Galvani, Elena
Campana, Luca G
De Rosa, F.
Gupta, Avinash
Weightman, John
Mills, Sarah
Dhomen, Nathalie
Citations
Altmetric:
Abstract
Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
Description
Date
2021
Publisher
Collections
Files
Loading...
From UNPAYWALL
Adobe PDF, 1.4 MB
Keywords
Type
Article
Citation
Valpione S, Mundra PA, Galvani E, Campana LG, Lorigan P, De Rosa F, et al. The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival. Nat Commun. 2021 Jul 2;12(1).