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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.

Andreassen, C
; 
Rosenstein, B
; 
Kerns, S
; 
Ostrer, H
; 
De Ruysscher, D
; 
Cesaretti, J
; 
Barnett, G
; 
Dunning, A
; 
Dorling, L
; 
West, Catharine M L
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Abstract
Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.
Authors
Andreassen, C
Rosenstein, B
Kerns, S
Ostrer, H
De Ruysscher, D
Cesaretti, J
Barnett, G
Dunning, A
Dorling, L
West, Catharine M L
Burnet, N
Elliott, R
Coles, C
Hall, E
Fachal, L
Vega, A
Gómez-Caamaño, A
Talbot, C
Symonds, R
De Ruyck, K
Thierens, H
Ost, P
Chang-Claude, J
Seibold, P
Popanda, O
Overgaard, M
Dearnaley, D
Sydes, M
Azria, D
Koch, C
Parliament, M
Blackshaw, M
Sia, M
Fuentes-Raspall, M
Ramon Y Cajal, T
Barnadas, A
Vesprini, D
Gutiérrez-Enríquez, S
Mollà, M
Díez, O
Yarnold, J
Overgaard, J
Bentzen, S
Alsner, J
Affiliation
Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark.
Description
Date
2016-07-18
Publisher
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All Christie Publications
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Article
Citation
Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. 2016: Radiother Oncol
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Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/618573
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