A roadmap for the clinical implementation of optical-imaging biomarkers
Waterhouse, D Fitzpatrick, C Pogue, B O'Connor, James P B Bohndiek, S
Waterhouse, D
Fitzpatrick, C
Pogue, B
O'Connor, James P B
Bohndiek, S
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Abstract
Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett's oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical-imaging technologies.
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Date
2019
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Collections
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Type
Article
Citation
Waterhouse DJ, Fitzpatrick CRM, Pogue BW, O'Connor JPB, Bohndiek SE. A roadmap for the clinical implementation of optical-imaging biomarkers. Nat Biomed Eng. 2019.