Treatment-related leukaemia--a clinical and scientific challenge.
Ng, Antony Taylor, G Malcolm Eden, Tim O B
Ng, Antony
Taylor, G Malcolm
Eden, Tim O B
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Abstract
The development of a second tumour, including treatment-related leukaemia (TRL), is the most devastating complication of intensive cancer chemotherapy. This is especially relevant in the paediatric population as over 70% of children diagnosed with a malignancy will now live at least 5 years. Most TRLs are myeloid leukaemias and carry an overall poor prognosis when compared with their de novo counterparts. Despite the well known association with specific cytotoxic agents, improved understanding of the pathogenesis and risk factors of TRL is ultimately essential if we are to develop successful strategies for prevention and treatment. Here we review these aspects, together with the clinical and diverse biological features of this complication and the efficacy of current therapy.
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Date
2000-10
Publisher
Collections
Keywords
Leukaemia
Second Primary Cancer
Radiation-Induced Leukaemia
Second Primary Cancer
Radiation-Induced Leukaemia
Type
Article
Citation
Treatment-related leukaemia--a clinical and scientific challenge. 2000, 26 (5):377-91 Cancer Treat. Rev.