Incident cancer burden attributable to excess body mass index in 30 European countries.
Renehan, Andrew G Soerjomataram, Isabelle Tyson, Margaret Egger, Matthias Zwahlen, Marcel Coebergh, Jan-Willem Buchan, Iain
Renehan, Andrew G
Soerjomataram, Isabelle
Tyson, Margaret
Egger, Matthias
Zwahlen, Marcel
Coebergh, Jan-Willem
Buchan, Iain
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Abstract
Excess adiposity is associated with increased risks of developing adult malignancies. To inform public health policy and guide further research, the incident cancer burden attributable to excess body mass index (BMI >or= 25 kg/m(2)) across 30 European countries were estimated. Population attributable risks (PARs) were calculated using European- and gender-specific risk estimates from a published meta-analysis and gender-specific mean BMI estimates from a World Health Organization Global Infobase. Country-specific numbers of new cancers were derived from Globocan2002. A ten-year lag-period between risk exposure and cancer incidence was assumed and 95% confidence intervals (CI) were estimated in Monte Carlo simulations. In 2002, there were 2,171,351 new all cancer diagnoses in the 30 countries of Europe. Estimated PARs were 2.5% (95% CI 1.5-3.6%) in men and 4.1% (2.3-5.9%) in women. These collectively corresponded to 70,288 (95% CI 40,069-100,668) new cases. Sensitivity analyses revealed estimates were most influenced by the assumed shape of the BMI distribution in the population and cancer-specific risk estimates. In a scenario analysis of a plausible contemporary (2008) population, the estimated PARs increased to 3.2% (2.1-4.3%) and 8.6% (5.6-11.5%), respectively, in men and women. Endometrial, post-menopausal breast and colorectal cancers accounted for 65% of these cancers. This analysis quantifies the burden of incident cancers attributable to excess BMI in Europe. The estimates reported here provide a baseline for future modelling, and underline the need for research into interventions to control weight in the context of endometrial, breast and colorectal cancer.
Description
Date
2010-02-01
Publisher
Collections
Keywords
Cancer
Type
Article
Citation
Incident cancer burden attributable to excess body mass index in 30 European countries. 2010, 126 (3):692-702 Int. J. Cancer