Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.
Lees, Nicholas P Harrison, Kathryn L Hill, Elizabeth Hall, C Nicholas Margison, Geoffrey P Povey, Andrew C
Lees, Nicholas P
Harrison, Kathryn L
Hill, Elizabeth
Hall, C Nicholas
Margison, Geoffrey P
Povey, Andrew C
Citations
Altmetric:
Abstract
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
Description
Date
2002-07-15
Publisher
Collections
Keywords
Cecal Cancer
Cancer Proteins
Rectal Cancer
Sigmoid Cancer
Cancer Proteins
Rectal Cancer
Sigmoid Cancer
Type
Article
Citation
Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum. 2002, 87 (2):168-70 Br. J. Cancer