Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.
Jayson, Gordon C Hansen, S Miller, G Cole, Claire L Rushton, Graham Avizienyte, Egle Gardiner, J
Jayson, Gordon C
Hansen, S
Miller, G
Cole, Claire L
Rushton, Graham
Avizienyte, Egle
Gardiner, J
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Abstract
The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8).
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2015-09-18
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Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology. 2015, 51 (72):13846-9 Chem Commun