Inhibition of haemopoietic stem cell proliferation by a diffusible product of bone marrow cells.
Benestad, H B Testa, Nydia G Lajtha, L G
Benestad, H B
Testa, Nydia G
Lajtha, L G
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Abstract
In a double diffusion chamber (DC) culture system bone marrow cells elaborated diffusible factor(s) that prevented spleen colony-forming cells (CFU-S), but not PHA stimulated lymphocytes, from entering cell cycle. Mature granulocytes and macrophages did not produce such factors(s). Various number of steady-state or regenerating mouse bone marrow cells were cultured in single diffusion chamber for periods up to 7 d. After the initial cell loss,the net growth of CFU-S was inversely related to both total cell number and CFU-S number in DC. Diffusible factors rather than cell-to-cell contact appeared to be involved in the inhibition, even though we were not able to demonstrate inhibition of net growth of CFU-S with the double chamber approach.
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1978-01
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Inhibition of haemopoietic stem cell proliferation by a diffusible product of bone marrow cells. 1978, 20 (1):18-24 Scand J Haematol