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Mind the IQGAP.

Sanchez-Laorden, Berta
; 
Viros, Amaya
; 
Marais, Richard
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Abstract
The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.
Authors
Sanchez-Laorden, Berta
Viros, Amaya
Marais, Richard
Affiliation
Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.
Description
Date
2013-06-10
Publisher
Collections
All Paterson Institute for Cancer Research
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Type
Article
Citation
Mind the IQGAP. 2013, 23 (6):715-7 Cancer Cell
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/295470
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