Rapid early progression in glioblastoma: a comprehensive review of clinical, imaging and histopathological features
Waqar, M. Roncaroli, F. O'Leary, C. Forte, G. Wright, J. Parikh, Shefali Sudell, Lindsay Coope, D. Djoukhadar, I. Borst, Gerben
Waqar, M.
Roncaroli, F.
O'Leary, C.
Forte, G.
Wright, J.
Parikh, Shefali
Sudell, Lindsay
Coope, D.
Djoukhadar, I.
Borst, Gerben
Citations
Altmetric:
Abstract
Background and Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (RBE) from elevated linear energy transfer (LET). This study assesses variations in LET in the brainstem and spinal cord in proton treatment plans from European centres. Materials and Methods: Ten European PT centres using spot-scanning PT planned two paediatric posterior fossa cases: One overlapping partly with the brainstem and upper spinal cord, prescribed 54 Gy(RBE), and the second wrapping around these organs, prescribed 59.4 Gy(RBE). Dose-averaged LET distributions were assessed in volumes of the brainstem and spinal cord irradiated to over 50 Gy(RBE = 1.1). The maximum hinge angle effect on near-maximum RBE-weighted doses using the Unkelbach RBE model was also investigated. Results: In the first case, the mean LET in brainstem volumes receiving more than 50 Gy(RBE = 1.1) ranged from 2.8 keV/mu m to 3.6 keV/mu m across centres (median: 3.3 keV/mu m). In the second case, treatment plans showed a narrower range of mean LET in the brainstem, from 2.5 keV/mu m to 2.8 keV/mu m (median: 2.7 keV/mu m). There was no statistically significant impact of the maximum hinge angle. Conclusions: LET distributions vary across centres due to different techniques but are also influenced significantly by factors like shape and position of the target volume.
Description
Date
2024
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
Waqar M, Roncaroli F, O'Leary C, Forte G, Wright J, Parikh S, et al. RAPID EARLY PROGRESSION IN GLIOBLASTOMA: A COMPREHENSIVE REVIEW OF CLINICAL, IMAGING AND HISTOPATHOLOGICAL FEATURES. Neuro-oncology. 2024 NOV 11;26. PubMed PMID: WOS:001362565900033. English.