Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy.
Haller, J C Cairnduff, F Slack, G Schofield, J Whitehurst, Colin Tunstall, R Brown, S B Roberts, D J
Haller, J C
Cairnduff, F
Slack, G
Schofield, J
Whitehurst, Colin
Tunstall, R
Brown, S B
Roberts, D J
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Abstract
BACKGROUND: Superficial basal cell carcinomas of the skin (sBCC) often respond poorly to single-treatment aminolaevulinic acid-based photodynamic therapy (ALA-PDT), with a number of reports indicating a relapse rate of 50% or more. OBJECTIVES: To determine whether a second treatment at seven days can improve the response. METHODS: Twenty-six lesions were treated twice with ALA-PDT, with an interval of 7 days between the two treatment sessions. RESULTS: We observed a complete response rate of 100% 1 month after treatment. Only one lesion relapsed (16 months post-PDT), a relapse rate of 4% (median follow up 27 months; range 15-45 months). Cosmetic results were excellent. CONCLUSIONS: We consider routine double treatments with ALA-PDT to be an effective approach to the management of sBCC, particularly those located in anatomically difficult, or cosmetically sensitive, sites.
Description
Date
2000-12
Publisher
Collections
Keywords
Skin Cancer
Type
Article
Citation
Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy. 2000, 143 (6):1270-5 Br. J. Dermatol.