Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
Pappalardi, M. B. Keenan, K. Cockerill, Mark Kellner, W. A. Stowell, Alexandra Sherk, C. Wong, K. Pathuri, S. Briand, J. Steidel, M.
Pappalardi, M. B.
Keenan, K.
Cockerill, Mark
Kellner, W. A.
Stowell, Alexandra
Sherk, C.
Wong, K.
Pathuri, S.
Briand, J.
Steidel, M.
Citations
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Abstract
Authors
Pappalardi, M. B.
Keenan, K.
Cockerill, Mark
Kellner, W. A.
Stowell, Alexandra
Sherk, C.
Wong, K.
Pathuri, S.
Briand, J.
Steidel, M.
Chapman, Philip
Groy, A.
Wiseman, A. K.
McHugh, C. F.
Campobasso, N.
Graves, A. P.
Fairweather, E.
Werner, T.
Raoof, Ali
Butlin, Roger J
Rueda, L.
Horton, J. R.
Fosbenner, D. T.
Zhang, C.
Handler, J. L.
Muliaditan, M.
Mebrahtu, M.
Jaworski, J. P.
McNulty, D. E.
Burt, Charlotte
Eberl, H. C.
Taylor, A. N.
Ho, T.
Merrihew, S.
Foley, S. W.
Rutkowska, A.
Li, M.
Romeril, S. P.
Goldberg, Kristin
Zhang, X.
Kershaw, Christopher S
Bantscheff, M.
Jurewicz, A. J.
Minthorn, E.
Grandi, P.
Patel, M.
Benowitz, A. B.
Mohammad, H. P.
Gilmartin, A. G.
Prinjha, R. K.
Ogilvie, Donald
Carpenter, C.
Heerding, D.
Baylin, S. B.
Jones, P. A.
Cheng, X.
King, B. W.
Luengo, J. I.
Jordan, Allan M
Waddell, Ian D
Kruger, R. G.
McCabe, M. T.
Keenan, K.
Cockerill, Mark
Kellner, W. A.
Stowell, Alexandra
Sherk, C.
Wong, K.
Pathuri, S.
Briand, J.
Steidel, M.
Chapman, Philip
Groy, A.
Wiseman, A. K.
McHugh, C. F.
Campobasso, N.
Graves, A. P.
Fairweather, E.
Werner, T.
Raoof, Ali
Butlin, Roger J
Rueda, L.
Horton, J. R.
Fosbenner, D. T.
Zhang, C.
Handler, J. L.
Muliaditan, M.
Mebrahtu, M.
Jaworski, J. P.
McNulty, D. E.
Burt, Charlotte
Eberl, H. C.
Taylor, A. N.
Ho, T.
Merrihew, S.
Foley, S. W.
Rutkowska, A.
Li, M.
Romeril, S. P.
Goldberg, Kristin
Zhang, X.
Kershaw, Christopher S
Bantscheff, M.
Jurewicz, A. J.
Minthorn, E.
Grandi, P.
Patel, M.
Benowitz, A. B.
Mohammad, H. P.
Gilmartin, A. G.
Prinjha, R. K.
Ogilvie, Donald
Carpenter, C.
Heerding, D.
Baylin, S. B.
Jones, P. A.
Cheng, X.
King, B. W.
Luengo, J. I.
Jordan, Allan M
Waddell, Ian D
Kruger, R. G.
McCabe, M. T.
Affiliation
Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA
Description
Date
2021
Publisher
Keywords
Type
Article
Citation
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-17.