The pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy.
Stewart, Alan L Margison, Jennifer M Wilkinson, Peter M Lucas, S
Stewart, Alan L
Margison, Jennifer M
Wilkinson, Peter M
Lucas, S
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Abstract
An unambiguous and specific HPLC assay was used to determine the pharmacokinetics of 7-hydroxymethotrexate (7-OHMTX) following the administration of moderate-dose methotrexate (MTX) 100 mg X m-2 to 37 patients with advanced head and neck cancer. There was marked interpatient variation but patient exposure to 7-OHMTX was considerable. There was, however, no correlation between the amount of 7-OHMTX produced and either tumour response or patient toxicity.
Description
Date
1985
Publisher
Collections
Keywords
Head and Neck Cancer
Type
Article
Citation
The pharmacokinetics of 7-hydroxymethotrexate following medium-dose methotrexate therapy. 1985, 14 (2):165-7 Cancer Chemother Pharmacol