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Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - clinical associations in NSCLC patients of the ETOP Lungscape cohort.
Rulle, U Tsourti, Z Casanova, R Deml, K Verbeken, E Thunnissen, E Warth, A Cheney, R Sejda, A Speel, E
Rulle, U
Tsourti, Z
Casanova, R
Deml, K
Verbeken, E
Thunnissen, E
Warth, A
Cheney, R
Sejda, A
Speel, E
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Abstract
PTEN loss is frequently observed in NSCLC and associated with both PI3K activation and tumoral immunosuppression. PTEN immunohistochemistry is a valuable read-out, but lacks standardized staining protocol and cut-off value.
Authors
Rulle, U
Tsourti, Z
Casanova, R
Deml, K
Verbeken, E
Thunnissen, E
Warth, A
Cheney, R
Sejda, A
Speel, E
Madsen, L
Nonaka, Daisuke
Navarro, A
Sansano, I
Marchetti, A
Finn, S
Monkhorst, K
Kerr, K
Haberecker, M
Wu, C
Zygoura, P
Kammler, R
Geiger, T
Gendreau, S
Schulze, K
Vrugt, B
Wild, P
Moch, H
Weder, W
Ciftlik, A
Dafni, U
Peters, S
Bubendorf, L
Stahel, R
Soltermann, A
Tsourti, Z
Casanova, R
Deml, K
Verbeken, E
Thunnissen, E
Warth, A
Cheney, R
Sejda, A
Speel, E
Madsen, L
Nonaka, Daisuke
Navarro, A
Sansano, I
Marchetti, A
Finn, S
Monkhorst, K
Kerr, K
Haberecker, M
Wu, C
Zygoura, P
Kammler, R
Geiger, T
Gendreau, S
Schulze, K
Vrugt, B
Wild, P
Moch, H
Weder, W
Ciftlik, A
Dafni, U
Peters, S
Bubendorf, L
Stahel, R
Soltermann, A
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Date
2018-09-18
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Article
Citation
Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - clinical associations in NSCLC patients of the ETOP Lungscape cohort. 2018, J Thorac Oncol