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Reappraisal of L-canavanine as an anti-tumour agent.
Naha, P M Silcock, Justine M Fellows, L
Naha, P M
Silcock, Justine M
Fellows, L
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Abstract
L-canavanine, an analogue of L-arginine, is known to have a toxic effect on pathogens. In experiments performed on a specialised epithelial-like cell system which is conditionally transformable, L-canavanine appeared to exhibit (1) a reversible 'static' effect on exponentially growing cells at optimal concentration, and (2) a selectively toxic effect on proliferating cells. The capacity to recognise 'tumour cells' in a heterogeneous population of cells is of potential interest in cancer chemotherapy.
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1980-02
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Reappraisal of L-canavanine as an anti-tumour agent. 1980, 4 (2):155-66 Cell Biol. Int. Rep.