A linkage study in seven breast cancer families.
Teare, M Dawn Santibanez-Koref, Mauro F Wallace, S A White, Gavin R M Evans, D Gareth R Burnell, Liza D Harris, Martin Howell, Anthony Birch, Jillian M
Teare, M Dawn
Santibanez-Koref, Mauro F
Wallace, S A
White, Gavin R M
Evans, D Gareth R
Burnell, Liza D
Harris, Martin
Howell, Anthony
Birch, Jillian M
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Abstract
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.
Description
Date
1993-04
Publisher
Keywords
Breast Cancer
Hereditary Cancerous Syndromes
Hereditary Cancerous Syndromes
Type
Article
Citation
A linkage study in seven breast cancer families. 1993, 52 (4):786-8 Am. J. Hum. Genet.