Correlation of extent of ALK FISH positivity and crizotinib efficacy in three prospective studies of ALK-positive patients with non-small cell lung cancer.
Soria, J Ho, S Varella-Garcia, M Iafrate, A Solomon, B Shaw, A Mok, T Wu, Y Pestova, K
Soria, J
Ho, S
Varella-Garcia, M
Iafrate, A
Solomon, B
Shaw, A
Mok, T
Wu, Y
Pestova, K
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Abstract
In clinical trials of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) treated with crizotinib, evaluation of the relationship between the percentage of ALK-positive cells by fluorescence in situ hybridization (FISH)-particularly near the cutoff defining positive status-and clinical outcomes have been limited by small sample sizes.
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Date
2018-07-13
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Article
Citation
Correlation of extent of ALK FISH positivity and crizotinib efficacy in three prospective studies of ALK-positive patients with non-small cell lung cancer. 2018, Ann Oncol