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Amplification of epidermal growth factor receptor gene in renal cell carcinoma.
El-Hariry, Iman Powles, Thomas Lau, Mike R Sternberg, Cora N Ravaud, Alain Von der Maase, Hans Zantl, Niko Harper, Peter Rolland, Frédéric Audhuy, Bruno
El-Hariry, Iman
Powles, Thomas
Lau, Mike R
Sternberg, Cora N
Ravaud, Alain
Von der Maase, Hans
Zantl, Niko
Harper, Peter
Rolland, Frédéric
Audhuy, Bruno
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Abstract
Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
Description
Date
2010-03
Publisher
Collections
Keywords
Cancerous Gene Expression Regulation
Type
Article
Citation
Amplification of epidermal growth factor receptor gene in renal cell carcinoma. 2010, 46 (5):859-62 Eur J Cancer