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Aluminium in human breast tissue.
Exley, Christopher Charles, Lisa M Barr, Lester Martin, Claire Polwart, Anthony Darbre, Philippa D
Exley, Christopher
Charles, Lisa M
Barr, Lester
Martin, Claire
Polwart, Anthony
Darbre, Philippa D
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Abstract
Aluminium is omnipresent in everyday life and increased exposure is resulting in a burgeoning body burden of this non-essential metal. Personal care products are potential contributors to the body burden of aluminium and recent evidence has linked breast cancer with aluminium-based antiperspirants. We have used graphite furnace atomic absorption spectrometry (GFAAS) to measure the aluminium content in breast biopsies obtained following mastectomies. The aluminium content of breast tissue and breast tissue fat were in the range 4-437 nmol/g dry wt. and 3-192 nmol/g oil, respectively. The aluminium content of breast tissue in the outer regions (axilla and lateral) was significantly higher (P=0.033) than the inner regions (middle and medial) of the breast. Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.
Description
Date
2007-06-06
Publisher
Collections
Keywords
Breast Cancer
Breast Fat
Breast Tissue
Anitperspirant
Breast Fat
Breast Tissue
Anitperspirant
Type
Article
Citation
Aluminium in human breast tissue. 2007, 101 (9):1344-6 J. Inorg. Biochem.