Leiomyosarcoma showing partial synthetic-phase differentiation.
Eyden, Brian P Banerjee, Saumitra S
Eyden, Brian P
Banerjee, Saumitra S
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Abstract
An unusual leiomyosarcoma in the thigh of a 53-year-old woman is described. Tumor cells were spindled and positive for muscle immuno-markers. Some cells exhibited typical smooth-muscle ultrastructure--abundant myofilaments, focal densities, attachment plaques, plasmalemmal caveolae, and lamina. Others had fewer myofilaments and prominent rough endoplasmic reticulum. These features indicated a variable phenotype that included synthetic-phase (matrigenic) differentiation. Synthetic-phase cells were distinguished from myofibroblasts by typical smooth-muscle surface features in the absence of fibronexus junctions. In a subset of cells myofilaments were absent, but structures resembling solitary focal densities were identified. These are discussed as possible indicators of a primitive level of smooth-muscle differentiation.
Authors
Description
Date
2002
Publisher
Collections
Keywords
Second Primary Cancer
Soft Tissue Cancer
Biological Tumour Markers
Soft Tissue Cancer
Biological Tumour Markers
Type
Article
Citation
Leiomyosarcoma showing partial synthetic-phase differentiation., 26 (5):335-40 Ultrastruct Pathol