Treatment-related toxicity using prostate bed versus prostate bed and pelvic lymph node radiation therapy following radical prostatectomy: A national population-based study
Parry, M. G. Sujenthiran, A. Nossiter, J. Morris, M. Berry, B. Cathcart, P. Payne, H. Van der Meulen, J Aggawal, A.
Parry, M. G.
Sujenthiran, A.
Nossiter, J.
Morris, M.
Berry, B.
Cathcart, P.
Payne, H.
Van der Meulen, J
Aggawal, A.
Citations
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Abstract
Introduction & Objectives: There is debate about the effectiveness and toxicity of pelvic lymph node (PLN) irradiation when used for disease
recurrence following radical prostatectomy. This study compared the toxicity of radiation therapy (RT) to the prostate bed and pelvic lymph nodes
(PBPLN-RT) with prostate-bed only radiation therapy (PBO-RT).
Materials & Methods: Patients with prostate cancer who underwent post-prostatectomy RT in the English National Health Service between
2010-2016 were identified by using data from the Cancer Registry, the National Radiotherapy Dataset, and Hospital Episode Statistics, an
administrative database of all hospital admissions. Follow-up was available up to December 31, 2018. Validated indicators were used to identify
patients with ≥ Grade 2 gastrointestinal (GI) and genitourinary (GU) toxicity according to the presence of both a procedure code and diagnostic
code in patient Hospital Episode Statistics records. A competing risks regression analysis, with adjustment for patient and tumour characteristics,
estimated subdistribution hazard ratios by comparing GI and GU toxicity for PBPLN-RT vs. PBO-RT.
Results: 5-year cumulative incidences in the PBO-RT (n=5,087) and PBPLN-RT (n=593) groups was 18.2% and 15.9% for GI toxicity, respectively.
For GU toxicity it was and 19.1% and 20.7%, respectively. There was no difference in GI or GU toxicity between PBO-RT and PBPLN-RT (GI:
adjusted sHR, 0.90, 95% CI, 0.67 to 1.19; P=0.45); (GU: adjusted sHR, 1.18, 95% CI, 0.98 to 1.44; P=0.09).
Conclusions: Including PLNs in the radiation field following radical prostatectomy is not associated with a significant increase in rates of ≥ Grade
2 GI or GU toxicity at 5 years.
Description
Date
2021
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
Parry MG, Sujenthiran A, Nossiter J, Morris M, Berry B, Cathcart P, et al. Treatment-related toxicity using prostate bed versus prostate bed and pelvic lymph node radiation therapy following radical prostatectomy: A national population-based study. European Urology. 2021;79:S1673-S.