Guidelines on the use of systemic therapy in patients with advanced thyroid cancer
Wadsley, J. Beasley, M. Garcez, Kate Hoy, S. Newbold, K. Boelaert, K.
Wadsley, J.
Beasley, M.
Garcez, Kate
Hoy, S.
Newbold, K.
Boelaert, K.
Citations
Altmetric:
Abstract
With increasing understanding of the molecular alterations leading to thyroid cancers in recent years we have seen a rapid increase in the number of effective targeted systemic therapies available for patients with advanced thyroid cancer; firstly with the advent of the multi-kinase inhibitors and more recently with more specific RET, BRAF, MEK, ALK and NTRK inhibitors. Although these developments are very welcome, they have resulted in a paradigm shift in the management of advanced thyroid cancer to which thyroid oncologists have had to rapidly adapt, learning how to supervise treatment safely with novel agents, the management of novel toxicities, when and how to arrange molecular genetic testing of cancers and, perhaps most importantly, determining when the optimum time is to start these treatments in what can often be a relatively indolent, if progressive, disease. We hope that these guidelines will support clinicians in making these decisions with their patients, as well as signposting and providing useful supporting information both for patients and clinicians.
Affiliation
Description
Date
2022
Publisher
Collections
Keywords
Type
Article
Citation
Wadsley J, Beasley M, Garcez K, Hoy S, Newbold K, Boelaert K. Guidelines on the Use of Systemic Therapy in Patients with Advanced Thyroid Cancer. Clinical oncology (Royal College of Radiologists (Great Britain)). 2022 Nov 3. PubMed PMID: 36336580. Epub 2022/11/07. eng.