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Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.

Chadi, S
; 
Malcomson, Lee
; 
Ensor, J
; 
Riley, R
; 
Vaccaro, C
; 
Rossi, G
; 
Daniels, I
; 
Smart, N
; 
Osborne, M
; 
Beets, G
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Abstract
In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide variation in the proportion of patients with local regrowth. We did an individual participant data meta-analysis to investigate factors affecting occurrence of local regrowth.
Authors
Chadi, S
Malcomson, Lee
Ensor, J
Riley, R
Vaccaro, C
Rossi, G
Daniels, I
Smart, N
Osborne, M
Beets, G
Maas, M
Bitterman, D
Du, K
Gollins, S
Sun Myint, A
Smith, F
Saunders, Mark P
Scott, N
O'Dwyer, Sarah T
de Castro Araujo, R
Valadao, M
Lopes, A
Hsiao, C
Lai, C
Smith, R
Paulson, E
Appelt, A
Jakobsen, A
Wexner, S
Habr-Gama, A
Sao Julião, G
Perez, R
Renehan, Andrew G
Affiliation
Division of Surgical Oncology and General Surgery, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada
Description
Date
2018-10-11
Publisher
Collections
All Christie Publications
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Keywords
Type
Article
Citation
Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. 2018 Lancet Gastroenterol Hepatol
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Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/621332
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