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PRO-CTCAE vs REQUITE: a comparison of two patient reported outcome (PRO) measurement tools in a lung cancer population
Jordan, T. Califano, R. Coote, J. Falk, S. Harris, M. Mistry, H. Taylor, P. Woolf, D. Faivre-Finn, C.
Jordan, T.
Califano, R.
Coote, J.
Falk, S.
Harris, M.
Mistry, H.
Taylor, P.
Woolf, D.
Faivre-Finn, C.
Citations
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Abstract
Introduction: Symptom assessment and collection through the use
of patient reported outcomes (PROs) has been shown to improve the
accuracy of symptom collection, increase quality of life, delineate
between clinical trial arms and improve overall survival. This will
be the first study comparing concordance and patient preference for
two PRO questionnaires; the REQUITE Lung Questionnaire and the
PRO-CTCAE (Common Terminology Criteria for Adverse Events). The
main aims of this study are to correlate the PRO tools to clinician
reported outcomes and to assess correlation and patient preference
between the PRO tools.
Methods: In June 2018, lung cancer patients attending outpatient
clinics at the Christie NHS foundation Trust were recruited to the
study. Clinician reported outcomes were generated through patient
assessment with the CTCAE. Participants completed the PROCTCAE,
REQUITE and study evaluation questionnaires. REQUITE and
CTCAE concordance was assessed by calculating Spearmans rank
correlation coefficient. PRO-CTCAE concordance was demonstrated
by assessing linear predictors from ordinal logistic regression
analysis for Spearmans rank correlation coefficient and p-values
were generated.
Results: 63/65 (96.9%) of patients that provided written informed
consent completed the study. Pearsons Rho correlation between
the PRO tools was 0.8-0.83 (p<0.001). Correlation between the
CTCAE and the PRO-CTCAE ranged between 0.66-0.82 (p<0.001).
REQUITE and CTCAE correlation was higher for all symtom domains
(except shortness of breath) ranging between 0.79-0.91 (p<0.001).
Acceptable discrepancies within one grade were present in 96.8%
to 100% of symptom domains for REQUITE and in 92.1-96.8%% for
all domains in the PRO-CTCAE. 54% of the total participant cohort
favored the REQUITE questionnaire due to reduced subjectivity in
the questions and ease of use.
Conclusion: The REQUITE questionnaire has shown superior
correlation to clinician reported outcomes and higher patient
preference than the PRO-CTCAE. Based on the results of this study
we recommend the use of the REQUITE questionnaire in the lung cancer setting.
Description
Date
2019
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
Jordan T, Califano R, Coote J, Falk S, Harris M, Mistry H, et al. PRO-CTCAE vs REQUITE: a comparison of two patient reported outcome (PRO) measurement tools in a lung cancer population. Lung Cancer. 2019;127:S61-S.