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Removal of Centrosomal PP1 by NIMA Kinase Unlocks the MPF Feedback Loop to Promote Mitotic Commitment in S. pombe.
Grallert, Agnes Chan, Kuan Yoow Alonso-Nunez, Maria-Luisa Madrid, Marisa Biswas, Ashapurna Alvarez-Tabares, Isabel Connolly, Yvonne Tanaka, Kayoko Robertson, Alasdair M Ortiz, J
Grallert, Agnes
Chan, Kuan Yoow
Alonso-Nunez, Maria-Luisa
Madrid, Marisa
Biswas, Ashapurna
Alvarez-Tabares, Isabel
Connolly, Yvonne
Tanaka, Kayoko
Robertson, Alasdair M
Ortiz, J
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Abstract
Activation of the Cdk1/cyclin B complex, also known as mitosis-promoting factor (MPF), drives commitment to mitosis. Interphase MPF is inhibited through phosphorylation of Cdk1 by Wee1-related kinases. Because Cdc25 phosphatases remove this phosphate, Cdc25 activity is an essential part of the switch that drives cells into mitosis. The generation of a critical "trigger" of active MPF promotes a positive feedback loop that employs Polo kinase to boost Cdc25 activity and inhibit Wee1, thereby ensuring that mitotic commitment is a bistable switch. Mutations in the spindle pole body (SPB) component Cut12 suppress otherwise lethal deficiencies in Cdc25.
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2013-02-04
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Article
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Removal of Centrosomal PP1 by NIMA Kinase Unlocks the MPF Feedback Loop to Promote Mitotic Commitment in S. pombe. 2013, 23 (3):213-22 Curr Biol