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Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro.
Haggie, J A Sellwood, R A Birch, Jillian M Schor, Seth L
Haggie, J A
Sellwood, R A
Birch, Jillian M
Schor, Seth L
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Abstract
Fetal and normal adult skin fibroblasts show distinctive migratory behaviour when plated on three-dimensional collagen gels. Skin fibroblasts from 13 of 15 patients with hereditary breast cancer showed fetal-like behaviour compared with only 1 of 12 age-matched healthy controls (p less than 0.015; Wilcoxon signed-rank matched-pairs test). In addition, 10 of 15 first-degree relatives of patients with hereditary breast cancer showed a fetal-like fibroblast phenotype, compared with none of 7 surgical controls (p less than 0.009; chi 2 test). These results suggest that abnormalities expressed by skin fibroblasts may help identify people at increased risk of breast cancer developing.
Affiliation
Description
Date
1987-06-27
Publisher
Collections
Keywords
Breast Cancer
Foetus
Foetus
Type
Article
Citation
Fibroblasts from relatives of patients with hereditary breast cancer show fetal-like behaviour in vitro. 1987, 1 (8548):1455-7 Lancet