FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas.
Dibb, M Han, N Choudhury, J Hayes, S Valentine, Helen R West, Catharine M L Sharrocks, A Ang, Y
Dibb, M
Han, N
Choudhury, J
Hayes, S
Valentine, Helen R
West, Catharine M L
Sharrocks, A
Ang, Y
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Abstract
Gastric cancers present late in life with advanced disease and carry a poor prognosis. Polo-like Kinase 1 (PLK1) is a mitotic kinase with regulatory functions during G2/M and mitosis in the cell cycle. In mammalian cells, there is an intricate co-regulatory relationship between PLK1 and the forkhead transcription factor FOXM1. It has been demonstrated that individually either PLK1 or FOXM1 expression predicts poorer survival. However, the co-expression of both of these markers in gastric adenocarcinomas has not been reported previously.
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Date
2015
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Collections
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Article
Citation
FOXM1 and polo-like kinase 1 are co-ordinately overexpressed in patients with gastric adenocarcinomas. 2015, 8:676 BMC Res Notes