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Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project.

Letovanec, I
; 
Finn, S
; 
Zygoura, P
; 
Smyth, P
; 
Soltermann, A
; 
Bubendorf, L
; 
Speel, E
; 
Marchetti, A
; ; 
Monkhorst, K
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Abstract
The reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort.
Authors
Letovanec, I
Finn, S
Zygoura, P
Smyth, P
Soltermann, A
Bubendorf, L
Speel, E
Marchetti, A
Nonaka, Daisuke
Monkhorst, K
Hager, H
Martorell, M
Sejda, A
Cheney, R
Hernandez-Losa, J
Verbeken, E
Weder, W
Savic, S
Di Lorito, A
Navarro, A
Felip, E
Warth, A
Baas, P
Meldgaard, P
Blackhall, Fiona H
Dingemans, A
Dienemann, H
Dziadziuszko, R
Vansteenkiste, J
O'Brien, C
Geiger, T
Sherlock, J
Schageman, J
Dafni, U
Kammler, R
Kerr, K
Thunnissen, E
Stahel, R
Peters, S
Affiliation
Institute of Pathology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
Description
Date
2017-11-27
Publisher
Collections
All Christie Publications
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Type
Article
Citation
Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project. 2017 J Thorac Oncol
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Volume Title
URI
http://hdl.handle.net/10541/620792
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