Randomised vehicle-controlled dose-finding study of glycosylated recombinant human granulocyte colony-stimulating factor after bone marrow transplantation.
Linch, D C Scarffe, J Howard Proctor, S Chopra, R Taylor, P R Morgenstern, Godfrey R Cunningham, D Burnett, A K Cawley, J C Franklin, I M
Linch, D C
Scarffe, J Howard
Proctor, S
Chopra, R
Taylor, P R
Morgenstern, Godfrey R
Cunningham, D
Burnett, A K
Cawley, J C
Franklin, I M
Citations
Altmetric:
Abstract
A multicentre, randomised vehicle-controlled single-blind dose ranging trial of intravenous recombinant granulocyte colony-stimulating factor (rhuG-CSF) administration after BMT has been performed in 121 patients with non-myeloid malignancies. All the doses of rhuG-CSF used (2-20 micrograms/kg/day) resulted in significant acceleration of neutrophil recovery, and a dose-response effect was apparent (p < 0.05). At the 20 micrograms/kg/day dose of rhuG-CSF the median time taken to achieve a neutrophil count of > 0.5 x 10(9)/1 was reduced from 19 to 13 days (p < 0.001) and the time to achieve a neutrophil count > 1.0 x 10(9)/1 on the first of 3 consecutive days, from 26 to 14 days (p < 0.001). There was a trend to less antibiotic use in the rhuG-CSF recipients and the median time in hospital was markedly reduced by 11-15 days (p < 0.01). There was no toxicity in this study attributable to rhuG-CSF.
Affiliation
Description
Date
1993-04
Publisher
Collections
Keywords
Cancer
Haematopoiesis
Haematopoiesis
Type
Article
Citation
Randomised vehicle-controlled dose-finding study of glycosylated recombinant human granulocyte colony-stimulating factor after bone marrow transplantation. 1993, 11 (4):307-11 Bone Marrow Transplant.